| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 5/12/2008 | DLC | Clemens | Released |   |   | Before |
| 5/12/2008 | DLC | Embree | Released |   |   | Before |
| 5/12/2008 | DLC | Laffey | Signed |   |   | Before |
| 5/12/2008 | DLC | Olson | Signed |   |   | Before |
| 5/12/2008 | DLC | Ross | Released |   |   | Before |
| 5/12/2008 | DLC | Shoppach | Signed |   |   | Before |
| 5/12/2008 | FFO | Hughes | Released |   |   | Before |
| 5/12/2008 | FFO | Sonnanstine | Signed |   |   | Before |
| 5/12/2008 | HHH | Borowski | Released |   |   | Before |
| 5/12/2008 | HHH | Fields | Signed |   |   | Before |
| 5/12/2008 | HHH | Parra | Signed |   |   | Before |
| 5/12/2008 | HHH | Towles | Released |   |   | Before |
| 5/12/2008 | JTL | Jones,A | Released |   |   | Before |
| 5/12/2008 | JTL | Torres | Signed |   |   | Before |
| 5/12/2008 | KW | Devine | Signed |   |   | Before |
| 5/12/2008 | KW | Reyes | Released |   |   | Before |
| 5/12/2008 | SCS | Johnson | Signed |   |   | Before |
| 5/12/2008 | SCS | Sanchez | Released |   |   | Before |
| 5/12/2008 | TS | Chavez | Released |   |   | Before |
| 5/12/2008 | TS | Geary | Released |   |   | Before |
| 5/12/2008 | TS | Headley | Signed |   |   | Before |
| 5/12/2008 | TS | Jimenez | Signed |   |   | Before |
| 5/12/2008 | TS | Ludwick | Signed |   |   | Before |
| 5/12/2008 | TS | Monroe | Released |   |   | Before |
| 5/12/2008 | TS | Shoppach | Released |   |   | Before |
| 5/12/2008 | TS | Shoppach | Signed |   |   | Before |
| 5/12/2008 | WBS | Ayala | Released |   |   | Before |
| 5/12/2008 | WBS | Capuano | Released |   |   | Before |
| 5/12/2008 | WBS | Carpenter | Signed |   |   | Before |
| 5/12/2008 | WBS | Colon | Signed |   |   | Before |
| 5/12/2008 | WBS | Johnson | Signed |   |   | Before |
| 5/12/2008 | WBS | Stewart | Released |   |   | Before |
| 5/26/2008 | HHH | Fields | Promoted to active roster |   |   | Before |
| 5/26/2008 | HHH | Tracy | Demoted to reserve roster |   |   | Before |
| 5/26/2008 | JTL | Howell | Signed |   |   | Before |
| 5/26/2008 | JTL | Iannetta | Signed |   |   | Before |
| 5/26/2008 | JTL | Kearns | Released |   |   | Before |
| 5/26/2008 | JTL | Lowry | Released |   |   | Before |
| 5/26/2008 | JTL | Nolasco | Signed |   |   | Before |
| 5/26/2008 | JTL | Otsuka | Released |   |   | Before |
| 5/26/2008 | JTL | Sanchez | Signed |   |   | Before |
| 5/26/2008 | JTL | Wolf | Released |   |   | Before |
| 5/26/2008 | WBS | Colon | Demoted to reserve roster |   |   | Before |
| 5/26/2008 | WBS | Colon | Promoted to active roster |   |   | Before |
| 5/26/2008 | WBS | Flores | Signed |   |   | Before |
| 5/26/2008 | WBS | Gabbard | Released |   |   | Before |
| 5/26/2008 | WBS | Johnson | Demoted to reserve roster |   |   | Before |
| 5/26/2008 | WBS | Jones | Signed |   |   | Before |
| 5/26/2008 | WBS | Kennedy | Released |   |   | Before |
| 5/26/2008 | WBS | Slowey | Promoted to active roster |   |   | Before |
| 5/26/2008 | WBS | Zumaya | Promoted to active roster |   |   | Before |
| 6/2/2008 | DLC | Buchholz | Demoted to reserve roster |   |   | Before |
| 6/2/2008 | DLC | Casilla | Signed |   |   | Before |
| 6/2/2008 | DLC | Easley | Signed |   |   | Before |
| 6/2/2008 | DLC | Frandsen | Signed |   |   | Before |
| 6/2/2008 | DLC | Gload | Released |   |   | Before |
| 6/2/2008 | DLC | Iguchi | Released |   |   | Before |
| 6/2/2008 | DLC | Linebrink | Promoted to active roster |   |   | Before |
| 6/2/2008 | DLC | Spiezio | Released |   |   | Before |
| 6/2/2008 | JTL | Balfour | Signed |   |   | Before |
| 6/2/2008 | JTL | Gonzalez | Released |   |   | Before |
| 6/2/2008 | JTL | Miller | Released |   |   | Before |
| 6/2/2008 | JTL | Ross | Signed |   |   | Before |
| 6/2/2008 | KW | Batista | Promoted to active roster |   |   | Before |
| 6/2/2008 | KW | Delcarmen | Demoted to reserve roster |   |   | Before |
| 6/2/2008 | KW | Devine | Promoted to active roster |   |   | Before |
| 6/2/2008 | TS | Barmes | Promoted to active roster |   |   | Before |
| 6/2/2008 | TS | Burke | Promoted to active roster |   |   | Before |
| 6/2/2008 | TS | Headley | Demoted to reserve roster |   |   | Before |
| 6/2/2008 | TS | Ludwick | Promoted to active roster |   |   | Before |
| 6/2/2008 | TS | Murphy | Demoted to reserve roster |   |   | Before |
| 6/2/2008 | TS | Willis | Demoted to reserve roster |   |   | Before |
| 6/2/2008 | WIN | Blackburn | Signed |   |   | Before |
| 6/2/2008 | WIN | Burres | Released |   |   | Before |
| 6/16/2008 | CRW | Blalock | Demoted to reserve roster |   |   | Before |
| 6/16/2008 | CRW | Bradley | Demoted to reserve roster |   |   | Before |
| 6/16/2008 | CRW | Hillenbrand | Promoted to active roster |   |   | Before |
| 6/16/2008 | CRW | Jenkins | Promoted to active roster |   |   | Before |
| 6/16/2008 | KW | Overbay | Demoted to reserve roster |   |   | Before |
| 6/16/2008 | SCS | Germano | Released |   |   | Before |
| 6/16/2008 | SCS | Pelfrey | Signed |   |   | Before |
| 6/16/2008 | SCS | Perez | Signed |   |   | Before |
| 6/16/2008 | SCS | Pineiro | Signed |   |   | Before |
| 6/16/2008 | SCS | Reyes | Released |   |   | Before |
| 6/16/2008 | SCS | Speier | Released |   |   | Before |
| 6/16/2008 | VA | Alfonzo | Demoted to reserve roster |   |   | Before |
| 6/30/2008 | CHA | Dotel | Demoted to reserve roster |   |   | Before |
| 6/30/2008 | CHA | Stanton | Promoted to active roster |   |   | Before |
| 6/30/2008 | DLC | Banks | Signed |   |   | Before |
| 6/30/2008 | DLC | Bay | Promoted to active roster |   |   | Before |
| 6/30/2008 | DLC | Campillo | Signed |   |   | Before |
| 6/30/2008 | DLC | Olson | Released |   |   | Before |
| 6/30/2008 | DLC | Snell | Released |   |   | Before |
| 6/30/2008 | FFO | Cabrera,A | Demoted to reserve roster |   |   | Before |
| 6/30/2008 | FFO | Davis | Promoted to active roster |   |   | Before |
| 6/30/2008 | FFO | Gallardo | Demoted to reserve roster |   |   | Before |
| 6/30/2008 | FFO | Schilling | Placed on disabled list |   | 6/16/2008 | Before |
| 6/30/2008 | FFO | Theriot | Promoted to active roster |   |   | Before |
| 6/30/2008 | FFO | Westbrook | Promoted to active roster |   |   | Before |
| 6/30/2008 | KW | Amezaga | Released |   |   | Before |
| 6/30/2008 | KW | Perkins | Signed |   |   | Before |
| 6/30/2008 | MMM | Gutierrez | Promoted to active roster |   |   | Before |
| 6/30/2008 | MMM | Soto | Demoted to reserve roster |   |   | Before |
| 6/30/2008 | WBS | Kearns | Signed |   |   | Before |
| 6/30/2008 | WBS | Sosa | Released |   |   | Before |
| 7/9/2008 | AAP | Floyd | Acquired via trade | JTL |   | After |
| 7/9/2008 | AAP | Lilly | Acquired via trade | JTL |   | After |
| 7/9/2008 | AAP | Wagner | Traded away | JTL |   | After |
| 7/9/2008 | HHH | Castillo | Traded away | WBS |   | After |
| 7/9/2008 | HHH | Wigginton | Acquired via trade | WBS |   | After |
| 7/9/2008 | JTL | Floyd | Traded away | AAP |   | After |
| 7/9/2008 | JTL | Lilly | Traded away | AAP |   | After |
| 7/9/2008 | JTL | Wagner | Acquired via trade | AAP |   | After |
| 7/9/2008 | WBS | Castillo | Acquired via trade | HHH |   | After |
| 7/9/2008 | WBS | Wigginton | Traded away | HHH |   | After |
| 7/10/2008 | AAP | Loaiza | Released |   |   | Before |
| 7/10/2008 | CRW | Donnelly | Promoted to active roster |   |   | Before |
| 7/10/2008 | CRW | Fultz | Promoted to active roster |   |   | Before |
| 7/10/2008 | CRW | Herges | Demoted to reserve roster |   |   | Before |
| 7/10/2008 | CRW | Moyer | Demoted to reserve roster |   |   | Before |
| 7/10/2008 | CRW | Romero | Demoted to reserve roster |   |   | Before |
| 7/10/2008 | CRW | Seay | Promoted to active roster |   |   | Before |
| 7/10/2008 | DLC | Bay | Demoted to reserve roster |   |   | Before |
| 7/10/2008 | DLC | Burke | Signed |   |   | Before |
| 7/10/2008 | DLC | Casilla | Promoted to active roster |   |   | Before |
| 7/10/2008 | DLC | Franklin | Released |   |   | Before |
| 7/10/2008 | DLC | Redding | Promoted to active roster |   |   | Before |
| 7/10/2008 | DLC | Shoppach | Placed on disabled list |   | 7/1/2008 | Before |
| 7/10/2008 | WBS | Colon | Released |   |   | Before |
| 7/10/2008 | WBS | Flores | Released |   |   | Before |
| 7/10/2008 | WBS | Garciaparra | Promoted to active roster |   |   | Before |
| 7/10/2008 | WBS | Molina | Demoted to reserve roster |   |   | Before |
| 7/10/2008 | WBS | Sanchez | Signed |   |   | Before |
| 7/10/2008 | WBS | Stewart | Signed |   |   | Before |
| 7/11/2008 | FFO | Schilling | Activated from disabled list |   |   | Before |
| 7/11/2008 | FFO | Theriot | Placed on disabled list |   | 7/10/2008 | Before |
| 7/23/2008 | CHA | Byrdak | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | CHA | Gordon | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | CHA | Lamb | Promoted to active roster |   |   | Before |
| 7/23/2008 | CHA | Marshall | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | CHA | Punto | Promoted to active roster |   |   | Before |
| 7/23/2008 | CHA | Thatcher | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | CHA | Wilkerson | Promoted to active roster |   |   | Before |
| 7/23/2008 | CHA | Williams | Promoted to active roster |   |   | Before |
| 7/23/2008 | DLC | Hill | Released |   |   | Before |
| 7/23/2008 | DLC | Lowry | Signed |   |   | Before |
| 7/23/2008 | FCB | Loretta | Promoted to active roster |   |   | Before |
| 7/23/2008 | FCB | Perez | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | HHH | Danks | Promoted to active roster |   |   | Before |
| 7/23/2008 | HHH | Miner | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | JTL | Drew | Promoted to active roster |   |   | Before |
| 7/23/2008 | JTL | Guardado | Signed |   |   | Before |
| 7/23/2008 | JTL | Madson | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | PIT | Buck | Promoted to active roster |   |   | Before |
| 7/23/2008 | PIT | Kendrick | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | SCS | Estrada | Released |   |   | Before |
| 7/23/2008 | SCS | Estrada | Signed |   |   | Before |
| 7/23/2008 | SCS | Gallagher | Signed |   |   | Before |
| 7/23/2008 | SCS | Kuo | Signed |   |   | Before |
| 7/23/2008 | SCS | Moylan | Released |   |   | Before |
| 7/23/2008 | SCS | Shealy | Released |   |   | Before |
| 7/23/2008 | TS | Cintron | Released |   |   | Before |
| 7/23/2008 | TS | Ellsbury | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | TS | Jurrjens | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | TS | Perez,T | Signed |   |   | Before |
| 7/23/2008 | TS | Taveras | Demoted to reserve roster |   |   | Before |
| 7/23/2008 | TS | Taveras | Promoted to active roster |   |   | Before |
| 7/23/2008 | TS | Upton | Promoted to active roster |   |   | Before |
| 7/23/2008 | TS | Villarreal | Promoted to active roster |   |   | Before |
| 7/23/2008 | TS | Willis | Promoted to active roster |   |   | Before |
| 8/3/2008 | AAP | Hamels | Traded away | WBS |   | After |
| 8/3/2008 | AAP | Jones | Acquired via trade | WBS |   | After |
| 8/3/2008 | AAP | Saltalamacchia | Acquired via trade | WBS |   | After |
| 8/3/2008 | AAP | Wood | Acquired via trade | WBS |   | After |
| 8/3/2008 | WBS | Hamels | Acquired via trade | AAP |   | After |
| 8/3/2008 | WBS | Jones | Traded away | AAP |   | After |
| 8/3/2008 | WBS | Saltalamacchia | Traded away | AAP |   | After |
| 8/3/2008 | WBS | Wood | Traded away | AAP |   | After |
| 8/4/2008 | AAP | Cedeno | Released |   |   | Before |
| 8/4/2008 | AAP | Rivera | Released |   |   | Before |
| 8/4/2008 | CHA | Schroder | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | CRW | Feliz | Promoted to active roster |   |   | Before |
| 8/4/2008 | CRW | Hillenbrand | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | DLC | Banks | Released |   |   | Before |
| 8/4/2008 | DLC | Dobbs | Signed |   |   | Before |
| 8/4/2008 | DLC | Easley | Released |   |   | Before |
| 8/4/2008 | DLC | Embree | Signed |   |   | Before |
| 8/4/2008 | DLC | Francisco | Signed |   |   | Before |
| 8/4/2008 | DLC | Lowry | Released |   |   | Before |
| 8/4/2008 | DLC | Ramirez | Signed |   |   | Before |
| 8/4/2008 | DLC | Redding | Released |   |   | Before |
| 8/4/2008 | FFO | Cabrera,A | Promoted to active roster |   |   | Before |
| 8/4/2008 | FFO | Figgins | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | FFO | Gagne | Released |   |   | Before |
| 8/4/2008 | FFO | Gagne | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | FFO | Gallardo | Promoted to active roster |   |   | Before |
| 8/4/2008 | FFO | Hamilton | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | FFO | Loney | Promoted to active roster |   |   | Before |
| 8/4/2008 | FFO | Nathan | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | FFO | Reyes | Signed |   |   | Before |
| 8/4/2008 | FFO | Sonnanstine | Promoted to active roster |   |   | Before |
| 8/4/2008 | FFO | Suzuki | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | FFO | Theriot | Activated from disabled list |   |   | Before |
| 8/4/2008 | FFO | Westbrook | Placed on disabled list |   | 8/3/2008 | Before |
| 8/4/2008 | HHH | Duke | Promoted to active roster |   |   | Before |
| 8/4/2008 | HHH | Kendrick | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | KW | Bailey | Released |   |   | Before |
| 8/4/2008 | KW | Delcarmen | Promoted to active roster |   |   | Before |
| 8/4/2008 | KW | McDonald | Signed |   |   | Before |
| 8/4/2008 | KW | Peralta | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | KW | Sheets | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | WBS | Gonzalez | Promoted to active roster |   |   | Before |
| 8/4/2008 | WBS | Molina | Promoted to active roster |   |   | Before |
| 8/4/2008 | WBS | Saltalamacchia | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | WBS | Slowey | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | WBS | Stewart | Demoted to reserve roster |   |   | Before |
| 8/4/2008 | WBS | Wood | Promoted to active roster |   |   | Before |
| 8/11/2008 | CHA | Marte | Demoted to reserve roster |   |   | Before |
| 8/11/2008 | DLC | Bailey | Signed |   |   | Before |
| 8/11/2008 | DLC | Dobbs | Released |   |   | Before |
| 8/11/2008 | DLC | Prado | Signed |   |   | Before |
| 8/11/2008 | FCB | Hampson | Demoted to reserve roster |   |   | Before |
| 8/11/2008 | SCS | Kuo | Promoted to active roster |   |   | Before |
| 8/11/2008 | SCS | Lannan | Demoted to reserve roster |   |   | Before |
| 8/11/2008 | WBS | Flores | Signed |   |   | Before |
| 8/11/2008 | WBS | Hughes | Signed |   |   | Before |
| 8/18/2008 | CRW | Coste | Demoted to reserve roster |   |   | Before |
| 8/18/2008 | JTL | Casilla | Demoted to reserve roster |   |   | Before |
| 8/18/2008 | JTL | Howell | Promoted to active roster |   |   | Before |
| 8/18/2008 | JTL | Martinez | Promoted to active roster |   |   | Before |
| 8/18/2008 | JTL | Ray | Demoted to reserve roster |   |   | Before |
| 8/18/2008 | JTL | Springer | Demoted to reserve roster |   |   | Before |
| 8/18/2008 | TS | Taveras | Demoted to reserve roster |   |   | Before |
| 8/18/2008 | VA | Hoffman | Demoted to reserve roster |   |   | Before |
| 8/25/2008 | CHA | Lugo | Promoted to active roster |   |   | Before |
| 8/25/2008 | CHA | Miller | Promoted to active roster |   |   | Before |
| 8/25/2008 | CRW | Littleton | Promoted to active roster |   |   | Before |
| 8/25/2008 | DLC | Shoppach | Activated from disabled list |   |   | Before |
| 8/25/2008 | FCB | Aurilia | Promoted to active roster |   |   | Before |
| 8/25/2008 | FFO | Sonnanstine | Demoted to reserve roster |   |   | Before |
| 8/25/2008 | FFO | Westbrook | Activated from disabled list |   |   | Before |
| 8/25/2008 | JTL | Nolasco | Promoted to active roster |   |   | Before |
| 8/25/2008 | SCS | LaRoche | Promoted to active roster |   |   | Before |
| 8/25/2008 | VA | Baez | Promoted to active roster |   |   | Before |
| 8/25/2008 | VA | Cantu | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Backe | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Dellucci | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Floyd | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Jones | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Lee | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Saltalamacchia | Promoted to active roster |   |   | Before |
| 9/1/2008 | AAP | Torrealba | Promoted to active roster |   |   | Before |
| 9/1/2008 | CRW | Hillenbrand | Promoted to active roster |   |   | Before |
| 9/1/2008 | CRW | Moyer | Promoted to active roster |   |   | Before |
| 9/1/2008 | CRW | Romero | Promoted to active roster |   |   | Before |
| 9/1/2008 | FCB | Logan | Promoted to active roster |   |   | Before |
| 9/1/2008 | FCB | Piazza | Promoted to active roster |   |   | Before |
| 9/1/2008 | FCB | Podsednik | Promoted to active roster |   |   | Before |
| 9/1/2008 | FCB | Sweeney | Promoted to active roster |   |   | Before |
| 9/1/2008 | FCB | Vizquel | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Figgins | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Hamilton | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Nathan | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Padilla | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Silva | Promoted to active roster |   |   | Before |
| 9/1/2008 | FFO | Sonnanstine | Promoted to active roster |   |   | Before |
| 9/1/2008 | HHH | Harden | Promoted to active roster |   |   | Before |
| 9/1/2008 | HHH | Parra | Promoted to active roster |   |   | Before |
| 9/1/2008 | HHH | Tracy | Promoted to active roster |   |   | Before |
| 9/1/2008 | HHH | Volquez | Promoted to active roster |   |   | Before |
| 9/1/2008 | HHH | Wilson | Promoted to active roster |   |   | Before |
| 9/1/2008 | JTL | Guardado | Promoted to active roster |   |   | Before |
| 9/1/2008 | JTL | Iannetta | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Gonzalez | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Maybin | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Mora | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Overbay | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Peralta | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Perkins | Promoted to active roster |   |   | Before |
| 9/1/2008 | KW | Sheets | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | Doumit | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | Ensberg | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | Eveland | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | Hendrickson | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | O'Flaherty | Promoted to active roster |   |   | Before |
| 9/1/2008 | MMM | Reyes | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Baldelli | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Burton | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Castillo | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Johnson | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Millar | Promoted to active roster |   |   | Before |
| 9/1/2008 | PIT | Olsen | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Chamberlain | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Gallagher | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Johnson | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Keppinger | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Quentin | Promoted to active roster |   |   | Before |
| 9/1/2008 | SCS | Votto | Promoted to active roster |   |   | Before |
| 9/1/2008 | TS | Galarraga | Promoted to active roster |   |   | Before |
| 9/1/2008 | TS | Headley | Promoted to active roster |   |   | Before |
| 9/1/2008 | TS | Hochevar | Promoted to active roster |   |   | Before |
| 9/1/2008 | VA | Contreras | Promoted to active roster |   |   | Before |
| 9/1/2008 | VA | Encarnacion | Promoted to active roster |   |   | Before |
| 9/1/2008 | VA | Gomez | Promoted to active roster |   |   | Before |
| 9/1/2008 | VA | Jennings | Promoted to active roster |   |   | Before |
| 9/1/2008 | VA | Millwood | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Carpenter | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Flores | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Hughes | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Johnson | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Sanchez | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Slowey | Promoted to active roster |   |   | Before |
| 9/1/2008 | WBS | Stewart | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Blackburn | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Brown | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Crede | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Jackson | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Schumaker | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Sherrill | Demoted to reserve roster |   |   | Before |
| 9/1/2008 | WIN | Spilborghs | Promoted to active roster |   |   | Before |
| 9/1/2008 | WIN | Wheeler | Promoted to active roster |   |   | Before |
| 9/15/2008 | AAP | Litsch | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | AAP | Saunders | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | CHA | Glaus | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | DLC | Affeldt | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | DLC | Bay | Promoted to active roster |   |   | Before |
| 9/15/2008 | DLC | Campillo | Promoted to active roster |   |   | Before |
| 9/15/2008 | DLC | Duchscherer | Promoted to active roster |   |   | Before |
| 9/15/2008 | DLC | Laffey | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | DLC | Marmol | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | DLC | Ramirez | Promoted to active roster |   |   | Before |
| 9/15/2008 | DLC | Ryan | Promoted to active roster |   |   | Before |
| 9/15/2008 | DLC | Werth | Placed on disabled list |   | 9/8/2008 | Before |
| 9/15/2008 | FCB | Castro | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | FCB | Hernandez,O | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | FCB | Percival | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | HHH | Buchholz | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | JTL | Utley | Placed on disabled list |   | 9/14/2008 | Before |
| 9/15/2008 | MMM | Accardo | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | MMM | Byrd | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | MMM | Lidge | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | MMM | Tankersley | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | MMM | Vizcaino | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | PIT | Cordero | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | PIT | Oliver | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | SCS | Bergmann | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | SCS | Greinke | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | SCS | Kinsler | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | SCS | Neshek | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | SCS | Upton | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | TS | Fuentes | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | TS | Molina | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | TS | Perez,T | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | Damon | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | Downs | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | Iwamura | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | McLouth | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | Rincon | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | VA | Timlin | Demoted to reserve roster |   |   | Before |
| 9/15/2008 | WIN | Street | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | AAP | Ankiel | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | AAP | Lyon | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | AAP | Tejada | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | AAP | Wickman | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | CHA | Bonds | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | CHA | Turnbow | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | CHA | Weaver | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | CRW | Bradley | Promoted to active roster |   |   | Before |
| 9/22/2008 | DLC | Bannister | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | DLC | Saito | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | FCB | Burnett | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | FFO | Gallardo | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | FFO | McGowan | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | HHH | Hennessey | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | HHH | Vargas | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | JTL | Crawford | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | KW | Eckstein | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | MMM | Bard | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | MMM | Izturis | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | PIT | Weathers | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | SCS | Capps | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | SCS | Jenks | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | TS | Barmes | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | TS | Benoit | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | VA | Barrett | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | WIN | Baker | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | WIN | Marcum | Demoted to reserve roster |   |   | Before |
| 9/22/2008 | WIN | Valentin | Demoted to reserve roster |   |   | Before |