| Injuries | ||||||
| Duration | ||||||
| Date | Team | Name | Cause | Return | Orig | Left |
| 10/5/2008 | WBS | Suzuki | General | 10/6/2008 | 1 | 1 |
| 10/4/2008 | CRW | Feliz | General | 10/8/2008 | 4 | 3 |
| 9/12/2008 | PIT | Johnson | General | 10/11/2008 | 29 | 6 |
| 9/13/2008 | JTL | Utley | General | 10/13/2008 | 30 | 8 |
| 9/29/2008 | FCB | Escobar | General | 10/15/2008 | 16 | 10 |
| 9/28/2008 | WBS | Garciaparra | General | 10/15/2008 | 17 | 10 |
| 10/1/2008 | SCS | Youkilis | General | 10/16/2008 | 15 | 11 |
| 9/17/2008 | HHH | Nady | General | 10/17/2008 | 30 | 12 |
| 10/1/2008 | CHA | Alou | General | 10/31/2008 | 30 | 26 |