| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/19/2010 | DLC | Davis,C | Demoted to reserve roster | | | Before |
| 4/19/2010 | DLC | Gervacio | Promoted to active roster | | | Before |
| 4/19/2010 | DLC | Kilby | Promoted to active roster | | | Before |
| 4/19/2010 | DLC | Soriano,R | Demoted to reserve roster | | | Before |
| 5/3/2010 | PHI | Doumit | Promoted to active roster | | | Before |
| 5/3/2010 | PHI | Duensing | Demoted to reserve roster | | | Before |
| 5/3/2010 | PHI | Dye | Demoted to reserve roster | | | Before |
| 5/3/2010 | PHI | Marquis | Promoted to active roster | | | Before |
| 5/17/2010 | DLC | Avila | Released | | | Before |
| 5/17/2010 | DLC | Cecil | Signed | | | Before |
| 5/17/2010 | DLC | Cervelli | Signed | | | Before |
| 5/17/2010 | DLC | Hairston,S | Released | | | Before |
| 5/17/2010 | DLC | Meek | Signed | | | Before |
| 5/17/2010 | DLC | Meek | Demoted to reserve roster | | | Before |
| 5/17/2010 | DLC | Mijares | Released | | | Before |
| 5/31/2010 | DLC | Chacin | Signed | | | Before |
| 5/31/2010 | DLC | Duchscherer | Released | | | Before |
| 5/31/2010 | DLC | Kilby | Demoted to reserve roster | | | Before |
| 5/31/2010 | DLC | Soriano,R | Promoted to active roster | | | Before |
| 6/14/2010 | CRW | Coste | Promoted to active roster | | | Before |
| 6/14/2010 | CRW | Flores,J | Demoted to reserve roster | | | Before |
| 6/14/2010 | DLC | Caridad | Demoted to reserve roster | | | Before |
| 6/14/2010 | DLC | Meek | Promoted to active roster | | | Before |
| 6/28/2010 | CRW | Davies | Promoted to active roster | | | Before |
| 6/28/2010 | CRW | Hawksworth | Demoted to reserve roster | | | Before |
| 6/28/2010 | CRW | Morales,F | Promoted to active roster | | | Before |
| 6/28/2010 | CRW | Moyer | Demoted to reserve roster | | | Before |
| 6/28/2010 | WBS | Fox,J | Signed | | | Before |
| 6/28/2010 | WBS | Rodriguez,A | Placed on disabled list | | 6/12/2010 | Before |
| 7/8/2010 | DLC | Cecil | Promoted to active roster | | | Before |
| 7/8/2010 | DLC | Vargas,C | Demoted to reserve roster | | | Before |
| 7/8/2010 | FS | Ross,D | Demoted to reserve roster | | | Before |
| 7/8/2010 | FS | Teagarden | Promoted to active roster | | | Before |
| 7/8/2010 | WBS | Gonzalez,G | Signed | | | Before |
| 7/8/2010 | WBS | Martin,J | Signed | | | Before |
| 7/8/2010 | WBS | Navarro | Released | | | Before |
| 7/8/2010 | WBS | Outman | Released | | | Before |
| 7/8/2010 | WBS | Wieters | Promoted to active roster | | | Before |
| 7/19/2010 | FFO | Holland | Promoted to active roster | | | Before |
| 7/19/2010 | FFO | Millwood | Placed on disabled list | | 7/19/2010 | Before |
| 7/19/2010 | PHI | Duensing | Promoted to active roster | | | Before |
| 7/19/2010 | PHI | Pagan | Demoted to reserve roster | | | Before |
| 7/26/2010 | CRW | Eyre,S | Demoted to reserve roster | | | Before |
| 7/26/2010 | CRW | Seay | Promoted to active roster | | | Before |
| 7/26/2010 | WBS | Ankiel | Released | | | Before |
| 7/26/2010 | WBS | Rodriguez,A | Activated from disabled list | | | Before |
| 8/2/2010 | CRW | Bruney | Promoted to active roster | | | Before |
| 8/2/2010 | CRW | Davis,R | Demoted to reserve roster | | | Before |
| 8/2/2010 | DLC | Desmond | Promoted to active roster | | | Before |
| 8/2/2010 | DLC | Gervacio | Demoted to reserve roster | | | Before |
| 8/2/2010 | FFO | Freese | Demoted to reserve roster | | | Before |
| 8/2/2010 | FFO | McGehee | Demoted to reserve roster | | | Before |
| 8/2/2010 | FFO | Perez,C | Promoted to active roster | | | Before |
| 8/2/2010 | FFO | Roberts,R | Signed | | | Before |
| 8/2/2010 | FFO | Sonnanstine | Released | | | Before |
| 8/2/2010 | FS | Hunter,Tom | Demoted to reserve roster | | | Before |
| 8/2/2010 | FS | Looper | Promoted to active roster | | | Before |
| 8/2/2010 | WBS | Feliz,N | Promoted to active roster | | | Before |
| 8/2/2010 | WBS | Martin,J | Demoted to reserve roster | | | Before |
| 8/2/2010 | WBS | Martinez,P | Promoted to active roster | | | Before |
| 8/2/2010 | WBS | Romo | Demoted to reserve roster | | | Before |
| 8/12/2010 | CRW | Hawkins | Demoted to reserve roster | | | Before |
| 8/12/2010 | CRW | Moyer | Promoted to active roster | | | Before |
| 8/12/2010 | DLC | Caridad | Released | | | Before |
| 8/12/2010 | DLC | Cervelli | Demoted to reserve roster | | | Before |
| 8/12/2010 | DLC | Davis,C | Promoted to active roster | | | Before |
| 8/12/2010 | DLC | Parnell | Signed | | | Before |
| 8/12/2010 | FCB | Castro,R | Promoted to active roster | | | Before |
| 8/12/2010 | FCB | Zaun | Demoted to reserve roster | | | Before |
| 8/12/2010 | FFO | Cust | Promoted to active roster | | | Before |
| 8/12/2010 | FFO | Escobar,A | Demoted to reserve roster | | | Before |
| 8/12/2010 | FFO | Lewis,F | Promoted to active roster | | | Before |
| 8/12/2010 | FFO | Pierre | Demoted to reserve roster | | | Before |
| 8/12/2010 | FS | Fowler | Promoted to active roster | | | Before |
| 8/12/2010 | FS | Ramirez,M | Demoted to reserve roster | | | Before |